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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A
LigandBDBM50295884
Substrate/Competitorn/a
Meas. Tech.ChEMBL_578766 (CHEMBL1052339)
IC50 5000±n/a nM
Citation Akue-Gedu, RDebiton, EFerandin, YMeijer, LPrudhomme, MAnizon, FMoreau, P Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. Bioorg Med Chem17:4420-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Name:Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms:DYR1A_RAT | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | Dyrk | Dyrk1a
Type:Enzyme Catalytic Domain
Mol. Mass.:85573.59
Organism:RAT
Description:Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0 RAT::Q63470
Residue:763
Sequence:
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50295884
n/a
NameBDBM50295884
Synonyms:1-(4-(2-amino-4-(1-methyl-1H-indol-3-yl)pyrimidin-5-yl)phenyl)ethanone | CHEMBL560787
TypeSmall organic molecule
Emp. Form.C21H18N4O
Mol. Mass.342.3938
SMILESCC(=O)c1ccc(cc1)-c1cnc(N)nc1-c1cn(C)c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: