| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-2 |
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| Ligand | BDBM50295955 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578992 (CHEMBL1061441) |
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| Ki | 0.0056±n/a nM |
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| Citation |  Gao, Y; Ravert, HT; Kuwabara, H; Xiao, Y; Endres, CJ; Hilton, J; Holt, DP; Kumar, A; Alexander, M; Wong, DF; Dannals, RF; Horti, AG Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography. Bioorg Med Chem17:4367-77 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-2 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-2 |
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| Synonyms: | ACHA2_RAT | Acra2 | Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4 | Chrna2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58597.25 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P12389 |
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| Residue: | 511 |
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| Sequence: | MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDV
VIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIP
DIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGS
WTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRR
LPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSL
VIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRP
LPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYG
HGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAM
VVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
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| BDBM50295955 |
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| n/a |
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| Name | BDBM50295955 |
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| Synonyms: | 5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyridin-3-yl)methoxy)-2-chloropyridine | CHEMBL558513 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15Cl2N3O2 |
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| Mol. Mass. | 340.205 |
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| SMILES | Clc1ccc(Oc2cc(OC[C@@H]3CCCN3)cnc2Cl)cn1 |r| |
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| Structure | 
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