Reaction Details |
| Report a problem with these data |
Target | Neuronal acetylcholine receptor subunit alpha-2 |
---|
Ligand | BDBM50295955 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_578993 (CHEMBL1061442) |
---|
Ki | 4.1±n/a nM |
---|
Citation | Gao, Y; Ravert, HT; Kuwabara, H; Xiao, Y; Endres, CJ; Hilton, J; Holt, DP; Kumar, A; Alexander, M; Wong, DF; Dannals, RF; Horti, AG Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography. Bioorg Med Chem17:4367-77 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neuronal acetylcholine receptor subunit alpha-2 |
---|
Name: | Neuronal acetylcholine receptor subunit alpha-2 |
Synonyms: | ACHA2_RAT | Acra2 | Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4 | Chrna2 |
Type: | Enzyme |
Mol. Mass.: | 58597.25 |
Organism: | Rattus norvegicus (Rat) |
Description: | P12389 |
Residue: | 511 |
Sequence: | MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDV
VIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIP
DIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGS
WTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRR
LPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSL
VIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRP
LPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYG
HGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAM
VVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
|
|
|
BDBM50295955 |
---|
n/a |
---|
Name | BDBM50295955 |
Synonyms: | 5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyridin-3-yl)methoxy)-2-chloropyridine | CHEMBL558513 |
Type | Small organic molecule |
Emp. Form. | C15H15Cl2N3O2 |
Mol. Mass. | 340.205 |
SMILES | Clc1ccc(Oc2cc(OC[C@@H]3CCCN3)cnc2Cl)cn1 |r| |
Structure |
|