| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
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| Ligand | BDBM50295959 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579000 (CHEMBL1061449) |
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| Ki | 0.028±n/a nM |
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| Citation |  Gao, Y; Ravert, HT; Kuwabara, H; Xiao, Y; Endres, CJ; Hilton, J; Holt, DP; Kumar, A; Alexander, M; Wong, DF; Dannals, RF; Horti, AG Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography. Bioorg Med Chem17:4367-77 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-4 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
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| Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 70196.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P09483 |
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| Residue: | 630 |
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| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
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| BDBM50295959 |
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| n/a |
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| Name | BDBM50295959 |
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| Synonyms: | (S)-2-chloro-5-((1-methylpyrrolidin-2-yl)methoxy)-3-(2-(pyridin-4-yl)vinyl)pyridine | CHEMBL562523 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20ClN3O |
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| Mol. Mass. | 329.824 |
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| SMILES | CN1CCC[C@H]1COc1cnc(Cl)c(\C=C\c2ccncc2)c1 |r| |
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| Structure | 
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