| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 3 |
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| Ligand | BDBM50414495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579670 (CHEMBL1064090) |
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| EC50 | 257±n/a nM |
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| Citation |  Skinner, PJ; Webb, PJ; Sage, CR; Dang, TH; Pride, CC; Chen, R; Tamura, SY; Richman, JG; Connolly, DT; Semple, G 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett19:4207-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 3 |
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| Name: | Hydroxycarboxylic acid receptor 3 |
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| Synonyms: | G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44498.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GPR109B 0 HUMAN::P49019 |
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| Residue: | 387 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
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| BDBM50414495 |
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| n/a |
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| Name | BDBM50414495 |
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| Synonyms: | CHEMBL562675 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N3O2S2 |
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| Mol. Mass. | 319.402 |
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| SMILES | OC(=O)c1cc([nH]n1)N(Cc1cccs1)Cc1cccs1 |
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| Structure | 
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