Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHydroxycarboxylic acid receptor 3
LigandBDBM50208138
Substrate/Competitorn/a
Meas. Tech.ChEMBL_579668 (CHEMBL1064088)
EC50 4200±n/a nM
Citation Skinner, PJWebb, PJSage, CRDang, THPride, CCChen, RTamura, SYRichman, JGConnolly, DTSemple, G 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett19:4207-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 3
Name:Hydroxycarboxylic acid receptor 3
Synonyms:G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:Enzyme Catalytic Domain
Mol. Mass.:44498.06
Organism:Homo sapiens (Human)
Description:GPR109B 0 HUMAN::P49019
Residue:387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50208138
n/a
NameBDBM50208138
Synonyms:(+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid | 5-methyl-4-oxo-5-phenyl-4,5-dihydrofuran-2-carboxylic acid | CHEMBL278488 | acifran
TypeSmall organic molecule
Emp. Form.C12H10O4
Mol. Mass.218.2054
SMILESCC1(OC(=CC1=O)C(O)=O)c1ccccc1 |c:3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: