| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 3 |
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| Ligand | BDBM50296250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579712 (CHEMBL1053953) |
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| IC50 | >10±n/a nM |
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| Citation |  Parkkila, S; Innocenti, A; Kallio, H; Hilvo, M; Scozzafava, A; Supuran, CT The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. Bioorg Med Chem Lett19:4102-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 3 |
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| Name: | Carbonic anhydrase 3 |
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| Synonyms: | CA-III | CA3 | CAH3_HUMAN | Carbonate dehydratase III | Carbonic Anhydrase III | Carbonic anhydrase | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29562.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human cloned isozyme. |
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| Residue: | 260 |
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| Sequence: | MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
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| BDBM50296250 |
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| n/a |
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| Name | BDBM50296250 |
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| Synonyms: | (S,Z)-3-(2-hydroxy-5-(1-hydroxy-3-methylbutyl)-4-methoxyphenyl)acrylate | CHEMBL560175 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20O5 |
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| Mol. Mass. | 280.3163 |
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| SMILES | COc1cc(O)c(\C=C/C(O)=O)cc1[C@@H](O)CC(C)C |r| |
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| Structure | 
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