| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50296295 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_577393 (CHEMBL1056245) |
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| IC50 | 0.6±n/a nM |
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| Citation |  Uto, Y; Ogata, T; Kiyotsuka, Y; Miyazawa, Y; Ueno, Y; Kurata, H; Deguchi, T; Yamada, M; Watanabe, N; Takagi, T; Wakimoto, S; Okuyama, R; Konishi, M; Kurikawa, N; Kono, K; Osumi, J Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation. Bioorg Med Chem Lett19:4159-66 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_MOUSE | Scd1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41064.54 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1462109 |
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| Residue: | 355 |
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| Sequence: | MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEG
PPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWS
HRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGW
LLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVN
SLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTF
PFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
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| BDBM50296295 |
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| n/a |
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| Name | BDBM50296295 |
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| Synonyms: | CHEMBL552173 | N-(5-(3,5-bis(trifluoromethyl)benzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F6N2O4S |
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| Mol. Mass. | 520.445 |
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| SMILES | COc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)s1 |
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| Structure | 
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