Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-6

Ligand

BDBM50119774

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_581328 (CHEMBL1050978)

IC50

2±n/a nM

Citation

Zheng, F; McConnell, MJ; Zhan, CG; Dwoskin, LP; Crooks, PA QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorg Med Chem17:4477-85 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuronal acetylcholine receptor subunit alpha-6

Name:

Neuronal acetylcholine receptor subunit alpha-6

Synonyms:

Type:

PROTEIN

Mol. Mass.:

56943.53

Organism:

Rattus norvegicus

Description:

ChEMBL_1454451

Residue:

493

Sequence:

MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVT
VHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDI
VLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
YDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVI
PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLD
KTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTE
NSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVG
LFLQPLLGNTGAS

BDBM50119774

n/a

Name

BDBM50119774

Synonyms:

1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium)bromide | 1,12-di(3-methyl-1-pyridiniumyl)dodecane; with dibromide ions | 3-methyl-1-[6-(3-methylpyridinium-1-yl)dodecyl]pyridinium; Dibromide | CHEMBL54331 | N,N'-(1,12-dodecandiyl)-bis-pyridinium dibromide | N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide | N,N'-dodecane-1,12-diyl-bis-3-picoliniumdibromide | N,N'-dodecane-1,12-yl-bis-3-picolinium dibromide | N,N'-dodecylbis-picolinium bromide | mono(1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium))dibromide

Type

Small organic molecule

Emp. Form.

C24H38N2

Mol. Mass.

354.5708

SMILES

Cc1ccc[n+](CCCCCCCCCCCC[n+]2cccc(C)c2)c1

Structure