| Reaction Details |
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 | Report a problem with these data |
| Target | Fatty-acid amide hydrolase 1 [30-579] |
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| Ligand | BDBM50296484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_581832 (CHEMBL1064168) |
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| IC50 | 531±n/a nM |
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| Citation |  Hart, T; Macias, AT; Benwell, K; Brooks, T; D'Alessandro, J; Dokurno, P; Francis, G; Gibbons, B; Haymes, T; Kennett, G; Lightowler, S; Mansell, H; Matassova, N; Misra, A; Padfield, A; Parsons, R; Pratt, R; Robertson, A; Walls, S; Wong, M; Roughley, S Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett19:4241-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fatty-acid amide hydrolase 1 [30-579] |
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| Name: | Fatty-acid amide hydrolase 1 [30-579] |
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| Synonyms: | Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1 |
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| Type: | Single-pass membrane protein; homodimer |
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| Mol. Mass.: | 60474.00 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P97612 (aa 30-579) |
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| Residue: | 550 |
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| Sequence: | RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSG
ELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKG
HDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWK
SSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGC
VYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGY
YETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFL
QNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQH
EIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPV
TTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVE
QLMTPQKQPS
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| BDBM50296484 |
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| n/a |
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| Name | BDBM50296484 |
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| Synonyms: | (S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}piperidin-1-ylmethanone | CHEMBL555563 | VER-156084 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23Cl2N3O2 |
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| Mol. Mass. | 420.332 |
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| SMILES | Clc1ccc(cc1)[C@H](OC1CN(C1)C(=O)N1CCCCC1)c1cccnc1Cl |r| |
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| Structure | 
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