| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
|---|
| Ligand | BDBM50254445 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_582535 (CHEMBL1060868) |
|---|
| IC50 | 0.28±n/a nM |
|---|
| Citation |  Bell, IM; Bednar, RA; Corcoran, HA; Fay, JF; Gallicchio, SN; Johnston, VK; Hershey, JC; Miller-Stein, CM; Moore, EL; Mosser, SD; Roller, SA; Salvatore, CA; Theberge, CR; Wong, BK; Blair Zartman, C; Kane, SA; Williams, TM; Graham, SL; Vacca, JP The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists. Bioorg Med Chem Lett19:4740-2 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcitonin gene-related peptide type 1 receptor |
|---|
| Name: | Calcitonin gene-related peptide type 1 receptor |
|---|
| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52980.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16602 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
|---|
| BDBM50254445 |
|---|
| n/a |
|---|
| Name | BDBM50254445 |
|---|
| Synonyms: | (S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5,4-de]quinoxalin-1-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-yl)acetamide | CHEMBL512773 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H20N6O4 |
|---|
| Mol. Mass. | 480.4748 |
|---|
| SMILES | O=C(Cn1c2cccc3NC(=O)Cn(c23)c1=O)Nc1ccc2C[C@@]3(Cc2c1)C(=O)Nc1ncccc31 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
