Reaction Details |
| Report a problem with these data |
Target | Calcitonin gene-related peptide type 1 receptor |
---|
Ligand | BDBM50296784 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_582534 (CHEMBL1060867) |
---|
Ki | 0.23±n/a nM |
---|
Citation | Bell, IM; Bednar, RA; Corcoran, HA; Fay, JF; Gallicchio, SN; Johnston, VK; Hershey, JC; Miller-Stein, CM; Moore, EL; Mosser, SD; Roller, SA; Salvatore, CA; Theberge, CR; Wong, BK; Blair Zartman, C; Kane, SA; Williams, TM; Graham, SL; Vacca, JP The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists. Bioorg Med Chem Lett19:4740-2 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Calcitonin gene-related peptide type 1 receptor |
---|
Name: | Calcitonin gene-related peptide type 1 receptor |
Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52980.45 |
Organism: | Homo sapiens (Human) |
Description: | Q16602 |
Residue: | 461 |
Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
BDBM50296784 |
---|
n/a |
---|
Name | BDBM50296784 |
Synonyms: | (S)-2-(6-methyl-2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5,4-de]quinoxalin-1-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-yl)acetamide | CHEMBL560527 |
Type | Small organic molecule |
Emp. Form. | C27H22N6O4 |
Mol. Mass. | 494.5014 |
SMILES | CN1C(=O)Cn2c3c1cccc3n(CC(=O)Nc1ccc3C[C@@]4(Cc3c1)C(=O)Nc1ncccc41)c2=O |r| |
Structure |
|