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TargetProstaglandin D2 receptor 2
LigandBDBM50296848
Substrate/Competitorn/a
Meas. Tech.ChEMBL_582709 (CHEMBL1054971)
Ki 28±n/a nM
Citation Sandham, DAAdcock, CBala, KBarker, LBrown, ZDubois, GBudd, DCox, BFairhurst, RAFuregati, MLeblanc, CManini, JProfit, RReilly, JStringer, RSchmidt, ATurner, KLWatson, SJWillis, JWilliams, GWilson, C 7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists. Bioorg Med Chem Lett19:4794-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD294 antigen | Crth2 | G protein-coupled receptor 44 | Gpr44 | PD2R2_MOUSE | Ptgdr2
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42975.89
Organism:Mus musculus (mouse)
Description:Human embryonic kidney (HEK) 293(EBNA) cells were transfected with mouse CRTH2.
Residue:382
Sequence:
MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRM
RQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFL
LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIM
CYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRT
GRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNP
LLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIP
QLRPTRLIGWMRRGSAEVPQRV
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  Blast E-value cutoff:
BDBM50296848
n/a
NameBDBM50296848
Synonyms:2-(1-(3,4-difluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid | CHEMBL563949
TypeSmall organic molecule
Emp. Form.C16H12F2N2O4S
Mol. Mass.366.339
SMILESCc1c(CC(O)=O)c2cccnc2n1S(=O)(=O)c1ccc(F)c(F)c1
Structure
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