| Reaction Details |
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 | Report a problem with these data |
| Target | Nociceptin receptor |
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| Ligand | BDBM50296914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580796 (CHEMBL1059778) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Sugimoto, Y; Kobayashi, K; Asai, M; Ohno, A; Yamada, K; Ozaki, S; Ohta, H; Okamoto, O Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: exploration and optimization of alternative pyrazole structure. Bioorg Med Chem Lett19:4611-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nociceptin receptor |
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| Name: | Nociceptin receptor |
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| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40702.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41146 |
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| Residue: | 370 |
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| Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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| BDBM50296914 |
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| n/a |
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| Name | BDBM50296914 |
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| Synonyms: | (1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1-(6-methylpyridin-3-yl)-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine | CHEMBL561397 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27ClFN5 |
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| Mol. Mass. | 427.945 |
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| SMILES | CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| |
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| Structure | 
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