| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Ligand | BDBM50188092 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_580952 (CHEMBL1054917) |
|---|
| IC50 | 1580±n/a nM |
|---|
| Citation |  Ahmed, S; Shahid, I; Dhanani, S; Owen, CP Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)). Bioorg Med Chem Lett19:4698-701 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Synonyms: | CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57255.68 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P11715 |
|---|
| Residue: | 507 |
|---|
| Sequence: | MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
|
|
|
|---|
| BDBM50188092 |
|---|
| n/a |
|---|
| Name | BDBM50188092 |
|---|
| Synonyms: | 1-(4-iodobenzyl)-1H-imidazole | 4-iodobenzyl imidazole | CHEMBL427399 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H9IN2 |
|---|
| Mol. Mass. | 284.0963 |
|---|
| SMILES | Ic1ccc(Cn2ccnc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
