| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50297306 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_582987 (CHEMBL1051825) |
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| IC50 | 200±n/a nM |
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| Citation |  Moree, WJ; Li, BF; Jovic, F; Coon, T; Yu, J; Gross, RS; Tucci, F; Marinkovic, D; Zamani-Kord, S; Malany, S; Bradbury, MJ; Hernandez, LM; O'Brien, Z; Wen, J; Wang, H; Hoare, SR; Petroski, RE; Sacaan, A; Madan, A; Crowe, PD; Beaton, G Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. J Med Chem52:5307-10 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50297306 |
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| n/a |
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| Name | BDBM50297306 |
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| Synonyms: | CHEMBL540982 | {2-[3-(4-Fluoro-benzyl)-benzo[b]thiophen-2-yl]-ethyl}-dimethyl-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20FNS |
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| Mol. Mass. | 313.432 |
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| SMILES | CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1 |
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| Structure | 
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