Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50297308 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_582981 (CHEMBL1051819) |
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Ki | 1.3±n/a nM |
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Citation | Moree, WJ; Li, BF; Jovic, F; Coon, T; Yu, J; Gross, RS; Tucci, F; Marinkovic, D; Zamani-Kord, S; Malany, S; Bradbury, MJ; Hernandez, LM; O'Brien, Z; Wen, J; Wang, H; Hoare, SR; Petroski, RE; Sacaan, A; Madan, A; Crowe, PD; Beaton, G Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. J Med Chem52:5307-10 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM50297308 |
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n/a |
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Name | BDBM50297308 |
Synonyms: | (-)-Dimethyl-{2-[3-((R)-1-pyrazin-2-yl-ethyl)-1H-inden-2-yl]-ethyl}-amine | (R)-N,N-dimethyl-2-(3-(1-(pyrazin-2-yl)ethyl)-1H-inden-2-yl)ethanamine | CHEMBL556506 |
Type | Small organic molecule |
Emp. Form. | C19H23N3 |
Mol. Mass. | 293.406 |
SMILES | C[C@H](C1=C(CCN(C)C)Cc2ccccc12)c1cnccn1 |r,c:2| |
Structure |
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