Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50297420 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_582828 (CHEMBL1061664) |
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Ki | 2.01±n/a nM |
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Citation | White, JD; Juniku, R; Huang, K; Yang, J; Wong, DT Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters. J Med Chem52:5872-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50297420 |
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n/a |
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Name | BDBM50297420 |
Synonyms: | (Z)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-yl)cyclopropyl)methanamine Hydrochloride | CHEMBL553224 | N-methyl-1-((1S,2S)-2-(naphthalen-1-yloxy)-2-(thiophen-2-yl)cyclopropyl)methanamine hydrochloride |
Type | Small organic molecule |
Emp. Form. | C19H19NOS |
Mol. Mass. | 309.425 |
SMILES | CNC[C@@H]1C[C@@]1(Oc1cccc2ccccc12)c1cccs1 |r| |
Structure |
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