| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
|---|
| Ligand | BDBM50297478 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_586022 (CHEMBL1063579) |
|---|
| Ki | 1600±n/a nM |
|---|
| Citation |  Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors. Bioorg Med Chem Lett19:2891-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 10 |
|---|
| Name: | Mitogen-activated protein kinase 10 |
|---|
| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52586.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 464 |
|---|
| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
|
|
|
|---|
| BDBM50297478 |
|---|
| n/a |
|---|
| Name | BDBM50297478 |
|---|
| Synonyms: | 5-fluoro-3-(hydroxyimino)-1-(4-methoxybenzyl)indolin-2-one | CHEMBL564745 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H13FN2O3 |
|---|
| Mol. Mass. | 300.2844 |
|---|
| SMILES | COc1ccc(CN2C(=O)C(N=O)c3cc(F)ccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
