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TargetC-X-C chemokine receptor type 2
LigandBDBM50297748
Substrate/Competitorn/a
Meas. Tech.ChEMBL_584049 (CHEMBL1055929)
Ki 22±n/a nM
Citation Aki, CChao, JFerreira, JADwyer, MPYu, YChao, JMerritt, RJLai, GWu, MHipkin, RWFan, XGonsiorek, WFosseta, JRindgen, DFine, JLundell, DTaveras, AGBiju, P Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region. Bioorg Med Chem Lett19:4446-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 2
Name:C-X-C chemokine receptor type 2
Synonyms:C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:Protein
Mol. Mass.:40767.88
Organism:Homo sapiens (Human)
Description:P25025
Residue:360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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BDBM50297748
n/a
NameBDBM50297748
Synonyms:(R)-3-(2-hydroxyphenylamino)-4-(1-(5-methylfuran-2-yl)propylamino)cyclobut-3-ene-1,2-dione | CHEMBL551747
TypeSmall organic molecule
Emp. Form.C18H18N2O4
Mol. Mass.326.3465
SMILESCC[C@@H](Nc1c(Nc2ccccc2O)c(=O)c1=O)c1ccc(C)o1 |r|
Structure
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