Reaction Details |
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Target | Serine/threonine-protein kinase PLK1 |
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Ligand | BDBM50297982 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_584622 (CHEMBL1059123) |
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IC50 | 16±n/a nM |
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Citation | Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors. Bioorg Med Chem Lett19:4673-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PLK1 |
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Name: | Serine/threonine-protein kinase PLK1 |
Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 68277.16 |
Organism: | Homo sapiens (Human) |
Description: | P53350 |
Residue: | 603 |
Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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BDBM50297982 |
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n/a |
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Name | BDBM50297982 |
Synonyms: | 3-{(R)-1-[2-Chloro-4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenyl]-ethoxy}-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxylic acid amide | CHEMBL552348 |
Type | Small organic molecule |
Emp. Form. | C25H25ClN4O4S2 |
Mol. Mass. | 545.073 |
SMILES | C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCS(=O)(=O)CC2)cc1Cl |r| |
Structure |
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