| Reaction Details |
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 | Report a problem with these data |
| Target | Progesterone receptor |
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| Ligand | BDBM50298032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_585095 (CHEMBL1054361) |
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| IC50 | 8±n/a nM |
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| Citation |  Thompson, SK; Washburn, DG; Frazee, JS; Madauss, KP; Hoang, TH; Lapinski, L; Grygielko, ET; Glace, LE; Trizna, W; Williams, SP; Duraiswami, C; Bray, JD; Laping, NJ Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists. Bioorg Med Chem Lett19:4777-80 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Progesterone receptor |
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| Name: | Progesterone receptor |
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| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
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| Type: | Protein |
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| Mol. Mass.: | 98979.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06401 |
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| Residue: | 933 |
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| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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| BDBM50298032 |
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| n/a |
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| Name | BDBM50298032 |
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| Synonyms: | (S)-2-chloro-4-((2-chlorobenzyl)(1-(cyanomethyl)pyrrolidin-3-yl)amino)benzonitrile | CHEMBL539731 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18Cl2N4 |
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| Mol. Mass. | 385.29 |
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| SMILES | Clc1ccccc1CN([C@H]1CCN(CC#N)C1)c1ccc(C#N)c(Cl)c1 |r| |
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| Structure | 
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