| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50299083 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_591788 (CHEMBL1038777) |
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| IC50 | >10000±n/a nM |
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| Citation |  Saitoh, M; Kunitomo, J; Kimura, E; Iwashita, H; Uno, Y; Onishi, T; Uchiyama, N; Kawamoto, T; Tanaka, T; Mol, CD; Dougan, DR; Textor, GP; Snell, GP; Takizawa, M; Itoh, F; Kori, M 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem52:6270-86 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50299083 |
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| n/a |
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| Name | BDBM50299083 |
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| Synonyms: | (S)-3-(4-(ethylsulfinyl)phenyl)-5-(5-methylfuran-2-yl)benzofuran | CHEMBL574613 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18O3S |
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| Mol. Mass. | 350.431 |
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| SMILES | CC[S@](=O)c1ccc(cc1)-c1coc2ccc(cc12)-c1ccc(C)o1 |r| |
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| Structure | 
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