Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM50299238 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_589296 (CHEMBL1045676) |
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Ki | 295±n/a nM |
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Citation | Al-Tel, TH; Al-Qawasmeh, RA; Schmidt, MF; Al-Aboudi, A; Rao, SN; Sabri, SS; Voelter, W Rational design and synthesis of potent dibenzazepine motifs as beta-secretase inhibitors. J Med Chem52:6484-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM50299238 |
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n/a |
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Name | BDBM50299238 |
Synonyms: | CHEMBL578437 | Methyl 11-Oxo-N-(pyridin-4-yl)-10,11-dihydro-5H-dibenzo-[b,e][1,4]diazepine-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C19H14N4O2 |
Mol. Mass. | 330.3401 |
SMILES | O=C(Nc1ccncc1)c1ccc2c(Nc3ccccc3NC2=O)c1 |
Structure |
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