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TargetBeta-secretase 1
LigandBDBM50299238
Substrate/Competitorn/a
Meas. Tech.ChEMBL_589296
Ki 295±n/a nM
Citation Al-Tel THAl-Qawasmeh RASchmidt MFAl-Aboudi ARao SNSabri SSVoelter W Rational design and synthesis of potent dibenzazepine motifs as beta-secretase inhibitors. J Med Chem 52:6484-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 1
Name:Beta-secretase 1
Synonyms:ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:Protein
Mol. Mass.:55755.10
Organism:Homo sapiens (Human)
Description:P56817
Residue:501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50299238
n/a
NameBDBM50299238
Synonyms:CHEMBL578437 | Methyl 11-Oxo-N-(pyridin-4-yl)-10,11-dihydro-5H-dibenzo-[b,e][1,4]diazepine-3-carboxamide
TypeSmall organic molecule
Emp. Form.C19H14N4O2
Mol. Mass.330.3401
SMILESO=C(Nc1ccncc1)c1ccc2c(Nc3ccccc3NC2=O)c1
Structure
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