Reaction Details |
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Target | LIM domain kinase 1 |
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Ligand | BDBM50299585 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_592394 (CHEMBL1036967) |
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IC50 | 6.6±n/a nM |
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Citation | Harrison, BA; Whitlock, NA; Voronkov, MV; Almstead, ZY; Gu, KJ; Mabon, R; Gardyan, M; Hamman, BD; Allen, J; Gopinathan, S; McKnight, B; Crist, M; Zhang, Y; Liu, Y; Courtney, LF; Key, B; Zhou, J; Patel, N; Yates, PW; Liu, Q; Wilson, AG; Kimball, SD; Crosson, CE; Rice, DS; Rawlins, DB Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem52:6515-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 1 |
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Name: | LIM domain kinase 1 |
Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 72591.81 |
Organism: | Homo sapiens (Human) |
Description: | gi_4505001 |
Residue: | 647 |
Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
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BDBM50299585 |
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n/a |
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Name | BDBM50299585 |
Synonyms: | (S)-N-(3-bromo-4-fluorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide | CHEMBL570820 |
Type | Small organic molecule |
Emp. Form. | C19H20BrFN6O |
Mol. Mass. | 447.304 |
SMILES | C[C@H]1CN(CCN1C(=O)Nc1ccc(F)c(Br)c1)c1ncnc2[nH]cc(C)c12 |r| |
Structure |
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