| Reaction Details |
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 | Report a problem with these data |
| Target | Cellular tumor antigen p53 |
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| Ligand | BDBM50299819 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_589609 (CHEMBL1052162) |
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| IC50 | 44300±n/a nM |
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| Citation |  Allen, JG; Bourbeau, MP; Wohlhieter, GE; Bartberger, MD; Michelsen, K; Hungate, R; Gadwood, RC; Gaston, RD; Evans, B; Mann, LW; Matison, ME; Schneider, S; Huang, X; Yu, D; Andrews, PS; Reichelt, A; Long, AM; Yakowec, P; Yang, EY; Lee, TA; Oliner, JD Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem52:7044-53 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cellular tumor antigen p53 |
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| Name: | Cellular tumor antigen p53 |
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| Synonyms: | Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53 |
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| Type: | fusion protein |
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| Mol. Mass.: | 43654.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The full-length His6-wt-p53 expressed in E. coli was used in assays. |
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| Residue: | 393 |
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| Sequence: | MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
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| BDBM50299819 |
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| n/a |
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| Name | BDBM50299819 |
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| Synonyms: | (+/-)-syn-6,7-Bis(4-bromophenyl)-2-fluoro-12-methyl-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | CHEMBL567403 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H17Br2FN4O |
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| Mol. Mass. | 568.235 |
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| SMILES | CN1c2ncnn2C(C2=C1c1cc(F)ccc1OC2c1ccc(Br)cc1)c1ccc(Br)cc1 |c:9| |
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| Structure | 
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