| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM50299853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_589681 (CHEMBL1057686) |
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| Ki | 6.3±n/a nM |
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| Citation |  Buchholz, M; Hamann, A; Aust, S; Brandt, W; Böhme, L; Hoffmann, T; Schilling, S; Demuth, HU; Heiser, U Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J Med Chem52:7069-80 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM50299853 |
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| n/a |
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| Name | BDBM50299853 |
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| Synonyms: | 1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol-1-yl)propyl)thiourea | CHEMBL566563 | US9656991, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N4O2S |
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| Mol. Mass. | 334.436 |
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| SMILES | COc1ccc(NC(=S)NCCCn2cncc2C)cc1OC |
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| Structure | 
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