| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
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| Ligand | BDBM31202 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_593610 (CHEMBL1039715) |
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| Ki | 1.7±n/a nM |
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| Citation |  Yu, S; Qin, D; Shangary, S; Chen, J; Wang, G; Ding, K; McEachern, D; Qiu, S; Nikolovska-Coleska, Z; Miller, R; Kang, S; Yang, D; Wang, S Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem52:7970-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 |
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| Name: | E3 ubiquitin-protein ligase Mdm2 |
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| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 55196.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987 |
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| Residue: | 491 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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| BDBM31202 |
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| n/a |
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| Name | BDBM31202 |
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| Synonyms: | JMC493432 Compound 8 | MI-63 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35Cl2FN4O3 |
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| Mol. Mass. | 577.518 |
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| SMILES | CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| |
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| Structure | 
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