Reaction Details |
| Report a problem with these data |
Target | Hematopoietic prostaglandin D synthase |
---|
Ligand | BDBM50186231 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_593692 (CHEMBL1044145) |
---|
IC50 | 1.223E5±n/a nM |
---|
Citation | Weber, JE; Oakley, AJ; Christ, AN; Clark, AG; Hayes, JD; Hall, R; Hume, DA; Board, PG; Smythe, ML; Flanagan, JU Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. Eur J Med Chem45:447-54 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hematopoietic prostaglandin D synthase |
---|
Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
|
|
|
BDBM50186231 |
---|
n/a |
---|
Name | BDBM50186231 |
Synonyms: | (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid | CHEMBL456 | ETHACRYNIC ACID | Edecrin | Etacrinic acid | Ethacrynate | Hydromedin | Methylenebutyrylphenoxyacetic acid | [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid | jm5b01461, Compound 72 |
Type | Small organic molecule |
Emp. Form. | C13H12Cl2O4 |
Mol. Mass. | 303.138 |
SMILES | CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl |
Structure |
|