| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase alpha catalytic subunit |
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| Ligand | BDBM50300195 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592717 (CHEMBL1042388) |
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| IC50 | >2E4±n/a nM |
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| Citation |  Yin, Z; Chen, YL; Kondreddi, RR; Chan, WL; Wang, G; Ng, RH; Lim, JY; Lee, WY; Jeyaraj, DA; Niyomrattanakit, P; Wen, D; Chao, A; Glickman, JF; Voshol, H; Mueller, D; Spanka, C; Dressler, S; Nilar, S; Vasudevan, SG; Shi, PY; Keller, TH N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase. J Med Chem52:7934-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase alpha catalytic subunit |
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| Name: | DNA polymerase alpha catalytic subunit |
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| Synonyms: | DNA polymerase (alpha/delta/epsilon) | DNA polymerase alpha subunit | DPOLA_HUMAN | POLA | POLA1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 165895.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1365493 |
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| Residue: | 1462 |
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| Sequence: | MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
LSRSGYSEVNLSKLFAGCAVKS
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| BDBM50300195 |
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| n/a |
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| Name | BDBM50300195 |
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| Synonyms: | 4-Fluoro-2-[3-(1-naphthalen-2-ylmethyl-1H-pyrazol-3-yl)-benzenesulfonylamino]-benzoic acid | CHEMBL566314 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H20FN3O4S |
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| Mol. Mass. | 501.529 |
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| SMILES | OC(=O)c1ccc(F)cc1NS(=O)(=O)c1cccc(c1)-c1cnn(Cc2ccc3ccccc3c2)c1 |
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| Structure | 
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