| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase beta |
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| Ligand | BDBM50300194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592718 (CHEMBL1042389) |
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| IC50 | >2E4±n/a nM |
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| Citation |  Yin, Z; Chen, YL; Kondreddi, RR; Chan, WL; Wang, G; Ng, RH; Lim, JY; Lee, WY; Jeyaraj, DA; Niyomrattanakit, P; Wen, D; Chao, A; Glickman, JF; Voshol, H; Mueller, D; Spanka, C; Dressler, S; Nilar, S; Vasudevan, SG; Shi, PY; Keller, TH N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase. J Med Chem52:7934-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase beta |
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| Name: | DNA polymerase beta |
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| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
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| Type: | Protein |
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| Mol. Mass.: | 38188.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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| BDBM50300194 |
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| n/a |
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| Name | BDBM50300194 |
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| Synonyms: | 2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylamino]-4-fluoro-benzoic acid | CHEMBL584918 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18FN3O4S |
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| Mol. Mass. | 451.47 |
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| SMILES | OC(=O)c1ccc(F)cc1NS(=O)(=O)c1cccc(c1)-c1cnn(Cc2ccccc2)c1 |
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| Structure | 
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