| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ALK tyrosine kinase receptor |
|---|
| Ligand | BDBM50300196 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_592724 (CHEMBL1042395) |
|---|
| Ki | 1.7E1±n/a nM |
|---|
| Citation |  Wang, T; Duffy, JP; Wang, J; Halas, S; Salituro, FG; Pierce, AC; Zuccola, HJ; Black, JR; Hogan, JK; Jepson, S; Shlyakter, D; Mahajan, S; Gu, Y; Hoock, T; Wood, M; Furey, BF; Frantz, JD; Dauffenbach, LM; Germann, UA; Fan, B; Namchuk, M; Bennani, YL; Ledeboer, MW Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. J Med Chem52:7938-41 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ALK tyrosine kinase receptor |
|---|
| Name: | ALK tyrosine kinase receptor |
|---|
| Synonyms: | ALK | ALK tyrosine kinase receptor (ALK) | ALK_HUMAN | Anaplastic lymphoma kinase | CD_antigen: CD246 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 176453.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UM73 |
|---|
| Residue: | 1620 |
|---|
| Sequence: | MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVV
PSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEA
RTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDY
FTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQ
MDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
YIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFF
ALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC
NFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFP
APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPL
LDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNP
NKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPL
KGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGE
DACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLII
AAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGA
TGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFIS
PLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVS
CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKL
SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPN
DPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMA
GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP
GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIIL
ERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAA
PPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPT
SLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS
SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
|
|
|
|---|
| BDBM50300196 |
|---|
| n/a |
|---|
| Name | BDBM50300196 |
|---|
| Synonyms: | 10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6.1.0^{2,7}.0^{14,18}]octadeca-1(18),2(7),3,5,11,14,16-heptaen-9-one | CHEMBL584052 | atropisomer 1 | atropisomer 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H15N3O2 |
|---|
| Mol. Mass. | 341.3627 |
|---|
| SMILES | Oc1ccc(cc1)C1c2c[nH]c3nccc(-c4ccccc4NC1=O)c23 |
|---|
| Structure | 
|
|---|
Search and Browse
