| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 2 |
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| Ligand | BDBM50300196 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592726 (CHEMBL1042397) |
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| Ki | 340±n/a nM |
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| Citation |  Wang, T; Duffy, JP; Wang, J; Halas, S; Salituro, FG; Pierce, AC; Zuccola, HJ; Black, JR; Hogan, JK; Jepson, S; Shlyakter, D; Mahajan, S; Gu, Y; Hoock, T; Wood, M; Furey, BF; Frantz, JD; Dauffenbach, LM; Germann, UA; Fan, B; Namchuk, M; Bennani, YL; Ledeboer, MW Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. J Med Chem52:7938-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase kinase 2 |
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| Name: | Mitogen-activated protein kinase kinase kinase kinase 2 |
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| Synonyms: | 2.7.11.1 | B lymphocyte serine/threonine-protein kinase | GC kinase | GCK | Germinal center kinase | M4K2_HUMAN | MAP4K2 | MAPK/ERK kinase kinase kinase 2 | MEK kinase kinase 2 | MEKKK 2 | RAB8IP | Rab8-interacting protein |
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| Type: | n/a |
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| Mol. Mass.: | 91551.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 820 |
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| Sequence: | MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ
EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA
LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP
EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT
RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE
DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG
KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP
LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG
CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL
LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ
CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE
LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE
RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD
ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
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| BDBM50300196 |
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| n/a |
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| Name | BDBM50300196 |
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| Synonyms: | 10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6.1.0^{2,7}.0^{14,18}]octadeca-1(18),2(7),3,5,11,14,16-heptaen-9-one | CHEMBL584052 | atropisomer 1 | atropisomer 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15N3O2 |
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| Mol. Mass. | 341.3627 |
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| SMILES | Oc1ccc(cc1)C1c2c[nH]c3nccc(-c4ccccc4NC1=O)c23 |
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| Structure | 
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