| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50300457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592009 (CHEMBL1050124) |
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| Ki | 47±n/a nM |
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| Citation |  Lange, JH; den Hartog, AP; van der Neut, MA; van Vliet, BJ; Kruse, CG Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists. Bioorg Med Chem Lett19:5675-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50300457 |
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| n/a |
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| Name | BDBM50300457 |
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| Synonyms: | 3-(4-chlorophenyl)-N'-(4,4-difluoropiperidin-1-ylsulfonyl)-N-methyl-4-phenyl-5,6-dihydropyridazine-1(4H)-carboximidamide | CHEMBL574172 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26ClF2N5O2S |
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| Mol. Mass. | 510 |
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| SMILES | CNC(=NS(=O)(=O)N1CCC(F)(F)CC1)N1CCC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:3.3,c:20| |
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| Structure | 
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