| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 2 |
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| Ligand | BDBM50300457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592011 (CHEMBL1050126) |
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| Ki | 247±n/a nM |
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| Citation |  Lange, JH; den Hartog, AP; van der Neut, MA; van Vliet, BJ; Kruse, CG Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists. Bioorg Med Chem Lett19:5675-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 2 |
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| Name: | Cannabinoid receptor 2 |
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| Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 39690.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34972 |
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| Residue: | 360 |
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| Sequence: | MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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| BDBM50300457 |
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| n/a |
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| Name | BDBM50300457 |
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| Synonyms: | 3-(4-chlorophenyl)-N'-(4,4-difluoropiperidin-1-ylsulfonyl)-N-methyl-4-phenyl-5,6-dihydropyridazine-1(4H)-carboximidamide | CHEMBL574172 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26ClF2N5O2S |
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| Mol. Mass. | 510 |
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| SMILES | CNC(=NS(=O)(=O)N1CCC(F)(F)CC1)N1CCC(C(=N1)c1ccc(Cl)cc1)c1ccccc1 |w:3.3,c:20| |
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| Structure | 
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