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TargetSodium-dependent noradrenaline transporter
LigandBDBM50300524
Substrate/Competitorn/a
Meas. Tech.ChEMBL_592526 (CHEMBL1044082)
IC50 10±n/a nM
Citation Mahaney, PEKim, CYCoghlan, RDCohn, STHeffernan, GDHuselton, CATerefenko, EAVu, ATZhang, PBurroughs, KDCosmi, SABray, JAJohnston, GHDeecher, DCTrybulski, EJ Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors. Bioorg Med Chem Lett19:5807-10 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:P23975
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50300524
n/a
NameBDBM50300524
Synonyms:(1S,2R)-1-(3-ethyl-1H-indol-1-yl)-1-(3-fluorophenyl)-3-(methylamino)propan-2-ol | CHEMBL576758
TypeSmall organic molecule
Emp. Form.C20H23FN2O
Mol. Mass.326.4078
SMILESCCc1cn([C@H]([C@H](O)CNC)c2cccc(F)c2)c2ccccc12 |r|
Structure
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