Reaction Details |
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Target | Liver carboxylesterase |
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Ligand | BDBM50300580 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_588965 (CHEMBL1056160) |
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Ki | 6640±n/a nM |
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Citation | Makhaeva, GF; Aksinenko, AY; Sokolov, VB; Serebryakova, OG; Richardson, RJ Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. Bioorg Med Chem Lett19:5528-30 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Liver carboxylesterase |
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Name: | Liver carboxylesterase |
Synonyms: | Carboxylesterase | EST1_PIG |
Type: | PROTEIN |
Mol. Mass.: | 62009.98 |
Organism: | Sus scrofa |
Description: | ChEMBL_427761 |
Residue: | 566 |
Sequence: | MWLLPLVLTSLASSATWAGQPASPPVVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPP
LGSLRFAPPQPAEPWSFVKNTTSYPPMCCQDPVVEQMTSDLFTNGKERLTLEFSEDCLYL
NIYTPADLTKRGRLPVMVWIHGGGLVLGGAPMYDGVVLAAHENVVVVAIQYRLGIWGFFS
TGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGESAGGESVSVLVLSPLAKNL
FHRAISESGVALTVALVRKDMKAAAKQIAVLAGCKTTTSAVFVHCLRQKSEDELLDLTLK
MKFLTLDFHGDQRESHPFLPTVVDGVLLPKMPEEILAEKDFNTVPYIVGINKQEFGWLLP
TMMGFPLSEGKLDQKTATSLLWKSYPIANIPEELTPVATDKYLGGTDDPVKKKDLFLDLM
GDVVFGVPSVTVARQHRDAGAPTYMYEFQYRPSFSSDKKPKTVIGDHGDEIFSVFGFPLL
KGDAPEEEVSLSKTVMKFWANFARSGNPNGEGLPHWPMYDQEEGYLQIGVNTQAAKRLKG
EEVAFWNDLLSKEAAKKPPKIKHAEL
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BDBM50300580 |
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n/a |
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Name | BDBM50300580 |
Synonyms: | CHEMBL575281 | Dimethyl 2,2,2-trifluoro-1-phenylethyl phosphate |
Type | Small organic molecule |
Emp. Form. | C10H12F3O4P |
Mol. Mass. | 284.1689 |
SMILES | COP(=O)(OC)OC(c1ccccc1)C(F)(F)F |
Structure |
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