Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50300602 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_588968 (CHEMBL1056163) |
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EC50 | 30±n/a nM |
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Citation | Iino, T; Sasaki, Y; Bamba, M; Mitsuya, M; Ohno, A; Kamata, K; Hosaka, H; Maruki, H; Futamura, M; Yoshimoto, R; Ohyama, S; Sasaki, K; Chiba, M; Ohtake, N; Nagata, Y; Eiki, J; Nishimura, T Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators. Bioorg Med Chem Lett19:5531-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50300602 |
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n/a |
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Name | BDBM50300602 |
Synonyms: | CHEMBL578638 | N-(1-ethyl-1H-pyrazol-3-yl)-6-(2-fluoro-6-(methylsulfonyl)phenoxy)quinazolin-4-amine |
Type | Small organic molecule |
Emp. Form. | C20H18FN5O3S |
Mol. Mass. | 427.452 |
SMILES | CCn1ccc(Nc2ncnc3ccc(Oc4c(F)cccc4S(C)(=O)=O)cc23)n1 |
Structure |
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