| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cysteine protease |
|---|
| Ligand | BDBM50268446 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_591545 (CHEMBL1062951) |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Mallari, JP; Shelat, AA; Kosinski, A; Caffrey, CR; Connelly, M; Zhu, F; McKerrow, JH; Guy, RK Structure-guided development of selective TbcatB inhibitors. J Med Chem52:6489-93 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cysteine protease |
|---|
| Name: | Cysteine protease |
|---|
| Synonyms: | Rhodesain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48425.78 |
|---|
| Organism: | Trypanosoma brucei rhodesiense |
|---|
| Description: | ChEMBL_619861 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
|
|
|
|---|
| BDBM50268446 |
|---|
| n/a |
|---|
| Name | BDBM50268446 |
|---|
| Synonyms: | CHEMBL496404 | methyl 3'-((2-cyano-9-(3-hydroxypropyl)-9H-purin-6-ylamino)methyl)biphenyl-3-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22N6O3 |
|---|
| Mol. Mass. | 442.4699 |
|---|
| SMILES | COC(=O)c1cccc(c1)-c1cccc(CNc2nc(nc3n(CCCO)cnc23)C#N)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
