| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM50258405 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_591547 (CHEMBL1062953) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Mallari, JP; Shelat, AA; Kosinski, A; Caffrey, CR; Connelly, M; Zhu, F; McKerrow, JH; Guy, RK Structure-guided development of selective TbcatB inhibitors. J Med Chem52:6489-93 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37819.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_63102437 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
|---|
| BDBM50258405 |
|---|
| n/a |
|---|
| Name | BDBM50258405 |
|---|
| Synonyms: | 6-((3',4'-dichlorobiphenyl-3-yl)methylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | CHEMBL495017 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H18Cl2N6O |
|---|
| Mol. Mass. | 453.324 |
|---|
| SMILES | OCCCn1cnc2c(NCc3cccc(c3)-c3ccc(Cl)c(Cl)c3)nc(nc12)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
