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TargetCathepsin L1
LigandBDBM50268446
Substrate/Competitorn/a
Meas. Tech.ChEMBL_591546
IC50 800±n/a nM
Citation Mallari JPShelat AAKosinski ACaffrey CRConnelly MZhu FMcKerrow JHGuy RK Structure-guided development of selective TbcatB inhibitors. J Med Chem 52:6489-93 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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  Blast E-value cutoff:
BDBM50268446
n/a
NameBDBM50268446
Synonyms:CHEMBL496404 | methyl 3'-((2-cyano-9-(3-hydroxypropyl)-9H-purin-6-ylamino)methyl)biphenyl-3-carboxylate
TypeSmall organic molecule
Emp. Form.C24H22N6O3
Mol. Mass.442.4699
SMILESCOC(=O)c1cccc(c1)-c1cccc(CNc2nc(nc3n(CCCO)cnc23)C#N)c1
Structure
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