| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform delta |
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| Ligand | BDBM50300886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599890 (CHEMBL1045455) |
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| IC50 | 2500±n/a nM |
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| Citation |  Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem52:7618-30 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform delta |
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| Name: | Casein kinase I isoform delta |
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| Synonyms: | CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta) |
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| Type: | Enzyme |
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| Mol. Mass.: | 47356.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48730 |
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| Residue: | 415 |
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| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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| BDBM50300886 |
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| n/a |
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| Name | BDBM50300886 |
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| Synonyms: | 4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | CHEMBL569552 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24FN3O2 |
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| Mol. Mass. | 381.4433 |
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| SMILES | CC(C)c1onc(c1-c1ccnc(NC2CCOCC2)c1)-c1ccc(F)cc1 |
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| Structure | 
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