| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform delta |
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| Ligand | BDBM50300889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599899 (CHEMBL1045464) |
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| IC50 | 330±n/a nM |
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| Citation |  Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem52:7618-30 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform delta |
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| Name: | Casein kinase I isoform delta |
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| Synonyms: | CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 47342.73 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q06486 |
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| Residue: | 415 |
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| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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| BDBM50300889 |
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| n/a |
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| Name | BDBM50300889 |
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| Synonyms: | CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridin-2-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18FN3O2 |
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| Mol. Mass. | 339.3635 |
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| SMILES | CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1 |
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| Structure | 
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