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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | ||
| Ligand | BDBM50300953 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_597981 (CHEMBL1045412) | ||
| IC50 | >2000±n/a nM | ||
| Citation |  Hughes, RO; Walker, JK; Rogier, DJ; Heasley, SE; Blevis-Bal, RM; Benson, AG; Jacobsen, EJ; Cubbage, JW; Fobian, YM; Owen, DR; Freskos, JN; Molyneaux, JM; Brown, DL; Acker, BA; Maddux, TM; Tollefson, MB; Moon, JB; Mischke, BV; Rumsey, JM; Zheng, Y; MacInnes, A; Bond, BR; Yu, Y Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one. Bioorg Med Chem Lett19:5209-13 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | |||
| Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | ||
| Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | Phosphodiesterase 3B | Phosphodiesterase 3B (PDE3B) | Phosphodiesterase Type 3 (PDE3B) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | cGMP-inhibited 3,5-cyclic phosphodiesterase B | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 124318.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | PDE3B was generated from the full-length recombinant human clone transfected into Sf9 cells. | ||
| Residue: | 1112 | ||
| Sequence: |
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| BDBM50300953 | |||
| n/a | |||
| Name | BDBM50300953 | ||
| Synonyms: | 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one | CHEMBL567470 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H31N5O4 | ||
| Mol. Mass. | 453.534 | ||
| SMILES | CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1 |r,wU:16.16,wD:19.20,(24.97,-.51,;23.64,-1.28,;23.64,-2.82,;22.3,-3.59,;22.3,-5.13,;20.97,-5.9,;20.97,-7.44,;22.3,-8.21,;23.62,-7.45,;24.95,-8.21,;24.95,-9.75,;23.62,-10.52,;22.3,-9.75,;20.97,-10.52,;19.62,-9.75,;18.29,-10.51,;16.96,-9.74,;15.63,-10.51,;14.29,-9.73,;14.3,-8.19,;12.97,-7.41,;15.64,-7.43,;16.97,-8.2,;19.64,-8.21,;18.31,-7.44,;26.28,-7.43,;27.61,-8.2,;28.94,-7.43,;28.94,-5.89,;30.27,-5.11,;31.61,-5.87,;27.59,-5.12,;26.27,-5.9,)| | ||
| Structure | 
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