| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
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| Ligand | BDBM50301077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598368 (CHEMBL1037272) |
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| IC50 | 0.070000±n/a nM |
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| Citation |  Wan, H; Huynh, T; Pang, S; Geng, J; Vaccaro, W; Poss, MA; Trainor, GL; Lorenzi, MV; Gottardis, M; Jayaraman, L; Purandare, AV Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies. Bioorg Med Chem Lett19:5063-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-arginine methyltransferase CARM1 |
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| Name: | Histone-arginine methyltransferase CARM1 |
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| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
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| Type: | Protein |
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| Mol. Mass.: | 65855.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86X55 |
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| Residue: | 608 |
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| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
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| BDBM50301077 |
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| n/a |
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| Name | BDBM50301077 |
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| Synonyms: | 2-(4-(2-(2,6-dimethoxyphenyl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperidin-1-yl)-N-methylethanamine | CHEMBL584335 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N4O2 |
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| Mol. Mass. | 408.5365 |
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| SMILES | CNCCN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(OC)cccc1OC |
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| Structure | 
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