Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50301159 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 18±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
| ||
| BDBM50301159 | |||
| n/a | |||
| Name | BDBM50301159 | ||
| Synonyms: | 1-(2-(dimethylamino)ethyl)-3-(4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)urea | CHEMBL565814 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27N7O | ||
| Mol. Mass. | 441.5282 | ||
| SMILES | CN(C)CCNC(=O)Nc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(10.72,-21.09,;10.76,-19.56,;9.44,-18.74,;12.11,-18.82,;12.16,-17.27,;10.84,-16.47,;10.88,-14.93,;9.57,-14.13,;12.24,-14.2,;13.55,-15,;14.9,-14.28,;16.21,-15.08,;16.16,-16.61,;17.48,-17.42,;17.43,-18.95,;16.08,-19.68,;14.76,-18.88,;14.81,-17.34,;13.51,-16.54,;18.84,-16.69,;19.31,-15.21,;18.82,-13.74,;20.06,-12.83,;21.31,-13.72,;20.85,-15.21,;21.33,-16.68,;20.07,-17.58,;20.07,-19.12,;18.74,-19.89,;18.74,-21.44,;20.07,-22.21,;21.41,-21.44,;21.41,-19.89,)| | ||
| Structure | 
| ||