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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM50148666 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_598612 (CHEMBL1048115) | ||
| IC50 | 48±n/a nM | ||
| Citation |  Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem44:4259-65 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
| ||
| BDBM50148666 | |||
| n/a | |||
| Name | BDBM50148666 | ||
| Synonyms: | 7-Chloro-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline | 7-chloro-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline | CHEMBL332344 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17ClN4 | ||
| Mol. Mass. | 360.839 | ||
| SMILES | Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2cc(Cl)ccc12 |(11.77,-3.83,;10.24,-4.04,;9.66,-5.47,;8.12,-5.67,;7.17,-4.46,;7.75,-3.03,;9.29,-2.82,;6.81,-1.82,;7.31,-.36,;6.07,.58,;5.62,2.03,;4.09,2.08,;3.58,.61,;4.81,-.31,;5.28,-1.8,;4.23,-2.92,;4.67,-4.41,;3.64,-5.54,;2.13,-5.19,;1.68,-3.72,;.17,-3.37,;-.28,-1.9,;-1.79,-1.55,;.77,-.77,;2.26,-1.1,;2.71,-2.59,)| | ||
| Structure | 
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