| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50301397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599955 (CHEMBL1048093) |
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| Ki | 16±n/a nM |
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| Citation |  Aslanian, R; Piwinski, JJ; Zhu, X; Priestley, T; Sorota, S; Du, XY; Zhang, XS; McLeod, RL; West, RE; Williams, SM; Hey, JA Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett19:5043-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50301397 |
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| n/a |
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| Name | BDBM50301397 |
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| Synonyms: | CHEMBL571390 | [1-(4-Methyl-benzyl)-piperidin-4-yl]-diphenyl-methanol |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29NO |
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| Mol. Mass. | 371.5146 |
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| SMILES | Cc1ccc(CN2CCC(CC2)C(O)(c2ccccc2)c2ccccc2)cc1 |
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| Structure | 
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