Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase Lck |
---|
Ligand | BDBM50301623 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_600521 (CHEMBL1049046) |
---|
IC50 | 3±n/a nM |
---|
Citation | Hunt, JA; Beresis, RT; Goulet, JL; Holmes, MA; Hong, XJ; Kovacs, E; Mills, SG; Ruzek, RD; Wong, F; Hermes, JD; Park, YW; Salowe, SP; Sonatore, LM; Wu, L; Woods, A; Zaller, DM; Sinclair, PJ Disubstituted pyrimidines as Lck inhibitors. Bioorg Med Chem Lett19:5440-3 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase Lck |
---|
Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
|
|
|
BDBM50301623 |
---|
n/a |
---|
Name | BDBM50301623 |
Synonyms: | (S)-N-(1-phenylethyl)-4-(5-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine | CHEMBL584721 |
Type | Small organic molecule |
Emp. Form. | C24H20N6 |
Mol. Mass. | 392.4558 |
SMILES | C[C@H](Nc1nccc(n1)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1 |r| |
Structure |
|