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Target5-hydroxytryptamine receptor 2C
LigandBDBM50301771
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598082 (CHEMBL1049772)
EC50>10000±n/a nM
Citation Andrews, MDGreen, MPAllerton, CMBatchelor, DVBlagg, JBrown, ADGordon, DWMcMurray, GMillns, DJNichols, CLWatson, L Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists. Bioorg Med Chem Lett19:5346-50 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2C
Name:5-hydroxytryptamine receptor 2C
Synonyms:5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:51836.79
Organism:Homo sapiens (Human)
Description:P28335
Residue:458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50301771
n/a
NameBDBM50301771
Synonyms:6-(3-chlorophenethyl)-3-methyl-2-(piperazin-1-yl)pyrimidin-4(3H)-one | CHEMBL577039
TypeSmall organic molecule
Emp. Form.C17H21ClN4O
Mol. Mass.332.828
SMILESCn1c(nc(CCc2cccc(Cl)c2)cc1=O)N1CCNCC1
Structure
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